It runs from the Takoradi Port to Kumasi with a branch line from Dunkwa to Awaso. It is a total of 339 kilometres. Today it is arguably the line that lends itself most readily to a BOT or BOOT Model of financing. This is because of the existence of various off takers and potential off takers on the route. Two mines are on this route. The Ghana Manganese Mine at Nsuta is 64 km from the port of Takoradi and relies on rail as well as road to transport manganese from Nsuta to the port of Takoradi. Its preferred mode of transportation is by rail and it is the inefficiency of the existing narrow gauge rail line, which compels it to use road, in addition to rail to transport manganese to the Takoradi Port.

There is a bauxite mine at Awaso, 239 km from Takoradi. This mine has used the rail network in the past, but it currently transports all its bauxite by road to the port of Takoradi because the rail line between Awaso and Nsuta, near Tarkwa, cannot be used. Opon Manso, which is also along the Western Line, has iron ore reserves of 150 million tons. This is yet to be exploited. Cocoa is also found along the corridor in commercial quantities and before the collapse of most of the Western Line, cocoa was transported in significant quantities by rail. The last time cocoa was transported by rail using the Western Line was 2006.

Transportation of other bulk cargo such as; cement, mining equipment and petroleum will also benefit from the construction of the rail line. Out of a total route length of 339 km, only 66 km from Takoradi to Nsuta is operational. The estimated investment required to construct a single standard gauge rail line along the Western Line is US$1, 898,400,000. Front End Engineering Designs have been completed and Government is ready to appoint a Transaction Advisor to advice on the EPC Contractor and the Funding Model. Significant proposals have been received including proposals for BOT and BOOT. The Western Line also connects to the Central Spine which terminates on the border with Burkina Faso at Paga.